(Solved by Humans)-A recent advance in cancer immunotherapy has been in activating

Question

A recent advance in cancer immunotherapy has been in activating the cellular immune response against cancer cells. Specific antibodies are injected into cancer patients in order to activate dormant or dying lymphocytes that are in or around tumors such that the lymphocytes then can kill the tumor cells.

a) (35 pts) Describe in detail the glycoproteins on the surface of the lymphocytes and the tumor cells that are responsible for shutting the lymphocytes down (what kind of proteins they are, their structures, etc.) and the mechanism of this inactivation (including signaling pathways). How do the therapeutic antibodies function to allow activation of the lymphocytes? Read and cite primary scientific literature, not just reviews or web pages from companies. Don?t simply rely on Wikipedia! Diagrams may aid your descriptions.

b) (15 pts) Describe any recent clinical data (2014 to present) from experiments that are evaluating, or have evaluated, the efficacy of these types of antibodies in treating a human cancer (choose the Highest quality published study you can find).